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Updated data from the ongoing phase 1/2 ECHO-204 trial evaluating the safety and efficacy of Epacadostat, an oral selective IDO1 enzyme inhibitor, in combination with Nivolumab ( Opdivo ), a PD-1 immu ...


Neuroendocrine tumors ( NETs ) are a heterogeneous class of neoplasms with increasing incidence worldwide. Tumor behavior and patient survival largely depend upon a number of different factors such ...


Taxanes are a mainstay in the treatment of metastatic breast cancer ( mBC ). Combination chemotherapy, including Platinum-taxens doublets, can improve tumor responses and progression-free survival ( P ...


Cardiomyocytes are resistant to radiation. However, cardiac radiation exposure causes coronary microvascular endothelial inflammation, a perturbation implicated in the pathogenesis of heart failure an ...


The European Commission ( EC ) has approved Varuby ( oral Rolapitant tablets ) for the prevention of delayed nausea and vomiting associated with highly and moderately emetogenic cancer chemotherapy in ...


A new study provides some of the strongest evidence to date that microorganisms living in the large intestine can serve as a link between diet and certain types of colorectal cancer, the lead authors ...


Ten years ago, the Adenoma Prevention With Celecoxib ( APC ) trial showed that the selective cyclooxygenase-2 ( COX-2 ) inhibitor reduced the incidence of post-polypectomy adenoma by 38% and advanced ...


Long-term, regular Aspirin ( Acetylsalicylic acid ) use was associated with reduced risk of death from several different kinds of cancers. Accumulating evidence suggests that Aspirin not only reduc ...


In a rigorous study of tumor tissue collected from 125 patients with aggressive brain cancers, researchers at Johns Hopkins say they have found no evidence of cytomegalovirus ( CMV ) infection and con ...


A phase II trial of Everolimus plus Octreotide LAR as first-line treatment for patients with previously untreated, well-differentiated gastroenteropancreatic NETs and NETs of lung origin, both functio ...


Researchers at the University of Texas MD Anderson Cancer Center in Houston, have found a link between microbes in the gut ( the microbiome ) and response to immunotherapy. In the study, the ability o ...


Indoleamine 2,3-dioxygenase-1 ( IDO1 ) catalyzes the degradation of tryptophan to N-formyl-kynurenine. Overexpressed in many solid malignancies, IDO1 can promote tumor escape from host immunosurveilla ...


The first-in-human results from a dose escalation study of Avitinib, a third generation irreversible epidermal growth factor receptor ( EGFR ) inhibitor that has been shown to overcome T790M-induced r ...


Sedation is used to an increasing extent in end-of-life care. Definitions and indications in this field are based on expert opinions and case series. Little is known about this practice at palliativ ...


The idea that a non-Platinum therapy might artificially extend the Platinum-free interval, thereby improving outcomes in ovarian cancer patients who experience recurrence between 6 and 12 months after ...