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Oncology Xagena

Prognostic factors for parotid metastasis of cutaneous squamous cell carcinoma of the head and neck


Cutaneous squamous cell carcinoma ( CSCC ) develops on the head in 80% of cases. Parotid metastasis is rare, but treatment, which associates surgery and radiation therapy, is heavy and prognosis poor.

All cases of parotidectomy for parotid metastasis of CSCC of the head and neck between 2005 and 2015 were studied retrospectively.

The principal study objective was to identify factors for survival in parotid metastasis from CSCC of the head and neck.

Thirty-five patients were included. Mean time to onset of parotid metastasis was 13months.

Overall 1-, 2- and 5-year survival was respectively 70, 66 and 59%.

Independent prognostic factors comprised immunodepression, age at treatment, positive CSCC margins, macroscopic facial nerve involvement, and metastatic cervical adenopathies.

In conclusion, the study has confirmed an association of several independent prognostic factors at the stage of parotid lymph-node metastasis, related to patient, primary CSCC and parotid metastasis.
Complete primary resection is essential to reduce the risk of parotid metastasis.
Intensified radiologic and clinical surveillance should enable early diagnosis. ( Xagena )

Bobin C et al, Eur Ann Otorhinolaryngol Head Neck Dis 2017; Epub ahead of print

XagenaMedicine_2017



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