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Advanced breast cancer: addition of Everolimus to Trastuzumab plus Vinorelbine significantly prolongs progression-free survival in patients with Trastuzumab-resistant and taxane-pretreated, HER2-positive


Disease progression in patients with HER2-positive breast cancer receiving Trastuzumab ( Herceptin ) might be associated with activation of the PI3K/Akt/mTOR intracellular signalling pathway.
Researchers have assessed whether the addition of the mTOR inhibitor Everolimus ( Afinitor ) to Trastuzumab might restore sensitivity to Trastuzumab.

In this randomised, double-blind, placebo-controlled, phase 3 trial, researchers recruited women with HER2-positive, Trastuzumab-resistant, advanced breast carcinoma who had previously received taxane therapy.

Eligible patients were randomly assigned ( 1:1 ) using a central patient screening and randomisation system to daily Everolimus ( 5 mg/day ) plus weekly Trastuzumab ( 2 mg/kg ) and Vinorelbine ( Navelbine ) ( 25 mg/m2 ) or to placebo plus Trastuzumab plus Vinorelbine, in 3-week cycles, stratified by previous Lapatinib use.

The primary endpoint was progression-free survival by local assessment in the intention-to-treat population.

The final analysis for progression-free survival was reported; overall survival follow-up is still in progress.

During the period 2009-2012, 569 patients were randomly assigned to Everolimus ( n=284 ) or placebo ( n=285 ). Median follow-up at the time of analysis was 20.2 months.

Median progression-free survival was 7.00 months with Everolimus and 5.78 months with placebo ( hazard ratio, HR=0.78; p=0.0067 ).

The most common grade 3-4 adverse events were neutropenia ( 73% in the Everolimus group vs 62% in the placebo group ), leucopenia ( 38% vs 29% ), anaemia ( 19% vs 6% ), febrile neutropenia ( 16% vs 4% ), stomatitis ( 13% vs 1% ), and fatigue ( 12% vs 4% ).

Serious adverse events were reported in 117 ( 42% ) patients in the Everolimus group and 55 ( 20% ) in the placebo group; two on-treatment deaths due to adverse events occurred in each group.

The addition of Everolimus to Trastuzumab plus Vinorelbine significantly prolongs progression-free survival in patients with Trastuzumab-resistant and taxane-pretreated, HER2-positive, advanced breast cancer.
The clinical benefit should be considered in the context of the adverse event profile in this population. ( Xagena )

André F et al, The Lancet Oncology 2014; 15: 580-591

XagenaMedicine_2014



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