Oncology Xagena
Detailed results from the phase 3 GLOW trial is evaluating first-line treatment with Zolbetuximab, a first-in-class claudin 18.2 ( CLDN18.2 ) targeted monoclonal antibody, plus CAPOX ( a combination c ...
In SPOTLIGHT, a global, randomised, placebo-controlled, double-blind, phase III study, Zolbetuximab, a monoclonal antibody targeting claudin-18 isoform 2 ( CLDN18.2 ) has significantly prolonged progr ...
In an analysis from the phase III ARASENS trial, clinical researchers found that the addition of Darolutamide ( Nubeqa ) to androgen-deprivation therapy ( ADT ) and Docetaxel has significantly improve ...
The objective of the study was to maintain living, interactive evidence ( LIvE ) on the benefits and harms of different treatment options in adults with cancer-associated thrombosis ( CAT ). Resear ...
Two-year ( 25.4 months minimum; 32.9 months median ) follow-up results from analyses of the phase 3 CheckMate -9ER trial, have demonstrated sustained survival and response rate benefits, as well as he ...
A systematic review and meta-analysis of 36 randomized clinical trials has suggested an association between the use of ICIs administered with CT and an increased risk of infections in patients with so ...
A systematic review and meta-analysis of 36 randomized clinical trials has suggested an association between the use of immune checkpoint inhibitors ( ICIs ) administered with chemotherapy and an incre ...
In CheckMate 577, Nivolumab ( Opdivo ) has demonstrated a significant and clinically meaningful improvement in disease-free survival ( DFS; primary endpoint ) versus placebo and was well tolerated in ...
New data from the phase 1/2 trial of Mobocertinib orally administered in previously treated patients with epidermal growth factor receptor ( EGFR ) exon20 insertion+ metastatic non-small cell lung can ...
Results from the phase 2 cohort of the CodeBreaK 100 clinical study evaluating investigational Sotorasib ( AMG 510 ) in 126 patients with KRAS G12C-mutated advanced non-small cell lung cancer ( NSCLC ...
New data from the phase 1 CHRYSALIS study, which has evaluated Amivantamab in patients with metastatic or unresectable non-small cell lung cancer ( NSCLC ) and epidermal growth factor receptor ( EGFR ...
Updated data from GARNET cohort F evaluating Dostarlimab in mismatch repair-deficient ( dMMR ) non-endometrial advanced solid cancers were presented at the 2021 American Society of Clinical Oncology ...
Patients with autoimmune disease and lung cancer pose a multidisciplinary treatment challenge, particularly with the advent of immunotherapy. However, the association between autoimmune disease and ...
NICOLAS is the first completed single-arm phase II trial in stage III non-small-cell lung cancer ( NSCLC ) examining hierarchically first the safety and then the efficacy of adding Nivolumab ( Opdivo ...
Consolidation Durvalumab after chemoradiation ( CRT ) is the current standard of care for locally advanced non-small-cell lung cancer ( NSCLC ). Researchers have hypothesized that adding immunothe ...
