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Oncology Xagena

Epacadostat is an oral, potent, selective inhibitor of indoleamine 2,3-dioxygenase 1 ( IDO1 ), a tryptophan-catabolizing enzyme that induces immune tolerance by T-cell suppression. Preliminary phase ...


The baseline serum cytokine levels of Platinum pretreated patients with advanced squamous non-small cell lung cancer ( NSCLC ) altered the efficacy of immunotherapy with Nivolumab ( Opdivo ), a fully ...


Two-year overall survival data from two pivotal phase 3 studies evaluating Nivolumab ( Opdivo ) versus Docetaxel in previously treated metastatic non-small cell lung cancer ( NSCLC ) were announced. ...


Patients with metastatic urothelial carcinoma have few treatment options after failure of Platinum-based chemotherapy. In this trial, researchers have assessed treatment with Atezolizumab, an engineer ...


Approximately a quarter of women with HER2 positive breast cancer, who were treated with a combination of the targeted drugs Lapatinib /( Tyverb; Tykerb ) and Trastuzumab ( Herceptin ) before surgery ...


The advent of new immunotherapies for the treatment of metastatic melanoma has resulted in various novel combination strategies. Because of their distinct modes of action, different immunotherapies ha ...


Treatment with programmed death receptor-1 ( PD-1 ) antibodies is associated with high response rates in patients with advanced melanoma. Reliable markers for early response and outcome are still spar ...


Updated results from the pivotal phase II study, IMvigor 210, of the investigational cancer immunotherapy Atezolizumab ( MPDL3280A ) in people with locally advanced or metastatic urothelial carcinoma ...


Trials of salvage therapy for advanced urothelial carcinoma have required prior Platinum-based therapy. This practice requires scrutiny since non-Platinum-based first-line therapy may be offered to Ci ...


The outcomes and therapy of advanced urothelial carcinoma ( UC ) patients following discontinuation of PD-1/PD-L1 inhibitors are unclear. Researchers performed a retrospective analysis to examine ...


Some parameters of the Comprehensive Geriatric Assessment ( CGA ) are predictive of chemotherapy toxicity. The Vulnerable Elders Survey-13 ( VES-13 ) is a short instrument that has been tested as a me ...


The majority of patients with castration-resistant prostate cancer develop bone metastatic disease. It is often challenging to optimally palliate malignant bone pain. In case of multifocal pain due to ...


A study has assessed palliative selective and superselective arterial embolization with N-butyl-cyanoacrylate ( n-BCA ) for cancer patients with spinal metastases. Researchers studied the files of ...


Bone metastases are common in patients with non-small cell lung cancer ( NSCLC ), often causing pain and a decrease in quality of life ( QoL ). The effect of bone-targeted agents is evaluated by reduc ...


Results from the pivotal KEYNOTE-010 study, the first study of its kind to evaluate the potential of an immunotherapy compared to chemotherapy based on prospective measurement of PD-L1 expression in p ...